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Nanomedicine in Cancer. Edited By Lajos P Balogh. Abstract - Engineering synthetic vaccines using cues from natural immunity Full text - Engineering synthetic vaccines using cues from natural immunity PDF KB - Engineering synthetic vaccines using cues from natural immunity. Nanoscale materials that deliver drugs in response to specific stimuli offer enhanced control of the drugs' release profile and distribution. This Review provides a comprehensive discussion of progress during the past five years in the design of nanoscale systems that can respond to exogenous stimuli such as temperature or variations in light or magnetic-field intensities, or to endogenous stimuli such as redox gradients or changes in pH or enzyme concentration.
Abstract - Stimuli-responsive nanocarriers for drug delivery Full text - Stimuli-responsive nanocarriers for drug delivery PDF 4, KB - Stimuli-responsive nanocarriers for drug delivery.
Nanotechnology and Drug Delivery
The use of macroscopic depots to deliver drugs — including small molecules, protein and cells — at the desired treatment site by using a carrier whose physical and chemical properties control the presentation of the drug increases drug effectiveness and reduces side effects. This Review discusses the advantages of macroscopic drug-delivery systems, the associated mechanisms of spatiotemporal control of drug presentation, and the design and use of multifunctional macroscopic drug-delivery devices. Abstract - Macroscale delivery systems for molecular and cellular payloads Full text - Macroscale delivery systems for molecular and cellular payloads PDF 2, KB - Macroscale delivery systems for molecular and cellular payloads.
My account Submit manuscript Register Subscribe. Top of page Commentaries Strategies for advancing cancer nanomedicine - pp - Vikash P.
Chauhan and Rakesh K. Jain doi With these and other nanoplatforms for targeted drug delivery being tested in animal models, medicine is now approaching the prototypic magic bullet, sparing healthy tissue while exterminating disease. In addition to serving as mere drug carriers that deliver the toxic payload to target cells, nanomaterials can themselves function as therapeutics.
For example, thermal energy is emerging as an important means of therapy, and many gold nanomaterials can convert photons into thermal energy for targeted photothermal therapy. Taking advantage of these properties, we conjugated aptamers onto the surfaces of gold-silver nanorods, which efficiently absorb near-infrared light and convert energy from photons to heat. These aptamer-conjugated nanorods were capable of selectively binding to target cells in culture and inducing dramatic cytotoxicity by converting laser light to heat.
Magnetic nanoparticles are also attractive for their ability to mediate heat induction. Jinwoo Cheon of Yonsei University in Korea developed core—shell magnetic nanoparticles, which efficiently generated thermal energy by a magnetization-reversal process as these nanoparticles returned to their relaxed states under an external, alternating-current magnetic field.
A third type of nanosize therapeutic involves cytotoxic polymers. For example, we synthesized a nucleotide-like molecule called an acrydite with an attached DNA aptamer that specifically binds to and enters target cancer cells. Many other subfields have been advanced by recent developments in nanomedicine, including tissue engineering and regenerative medicine, medical devices, and vaccines.
We must proceed with caution until these different technologies prove safe in patients, but nanomedicine is now poised to make a tremendous impact on health care and the practice of clinical medicine. Nano-fighters In addition to serving as mere drug carriers that deliver the toxic payload to target cells, nanomaterials can themselves function as therapeutics.
References W. Chan, S. Cutler et al. Liu et al. Sefah et al. Kang et al.
Nanomedicine for Drug Delivery and Therapeutics
Zhu et al. Lee et al. Ke et al. Morton et al. Douglas et al.
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